Balasubramaniyan

Dr Balasubramaniyan
Vairappan
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Select Department: 
Biochemistry
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Faculty and Staff
Designation: 
Associate Professor
Academic Qualifications: 

2017 July to present: Associate Professor, JIPMER, Pondicherry, India. 2013 November to present: Assistant Professor, JIPMER, Pondicherry, India. 2013 April to present: Ramalingaswami Fellow Scientist D, JIPMER, Pondicherry, India. 2007-2013: Postdoctoral Fellow, UCL Institute for Liver and Digestive Health, University College London (UCL), London, UK. 2003-2007: PhD, Annamalai University, Chidambaram, Tamilnadu, India, in collaboration with the National Centre for Cell Science (NCCS), Pune, India.
Teaching Experiences since 2013 1. Undergraduates – MBBS, MLT and Allied Medical Science (AMS) Courses 2. Postgraduates - M.Sc Medical Biochemistry

Special Area of Interest: 
Liver cirrhosis and portal hypertension
NAFLD & ALD
Liver cancer and cell signalling
Inflammation and immune regulatory mechanism in liver diseases
Publication: 

Total Publications - 41 Selected Publications 1. Balasubramaniyan V. Sundhar M, Srinivas BH. Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl4-Induced Cirrhotic Mice. Molecular Neurobiology 2018. Impact factor 5.2. 2. Balasubramaniyan V. Renal ammonia metabolism in liver diseases. Gastroenterol Hepatol Open Access. 2018;9(2):60–63. 3. Balasubramaniyan V, G Mehta, Jones H, V Sharma, Davies N.A, Jalan R, Mookerjee R.P. Post-Transcriptional Regulation of Hepatic DDAH-1 with TNFα Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats. Scientific Reports 2017; Dec 20;7(1):17900. Impact Factor 4.3 4. Sundhar M, Balasubramaniyan V. Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases. World J Hepatol 2017; 9(32): 1210-1226. Impact Factor 2.4 5. Jalan R, De Chiara F, Balasubramaniyan V, Andreola F, Khetan V, Malago M, Pinzani M, Mookerjee RP, Rombouts K. Ammonia produces pathological changes in human hepatic stellate cells and is a target of therapy of portal hypertension. Journal of Hepatology 2016; 64(4): 823-33. Impact Factor 12.4 6. Balasubramaniyan V. Endothelial dysfunction in cirrhosis: Role of inflammation and oxidative stress. World Journal of Hepatology 2015; 7(3): 443-59. Impact Factor 2.4 7. Mookerjee RP, Balasubramaniyan V, Mehta G, Mohamed F, Davies N, Sharma V, Iwakiri Y, Jalan R. Hepatic Dimethylarginine-Dimethylaminohydrolase1 is Reduced in Cirrhosis and is a Target for Therapy in Portal Hypertension. Journal of Hepatology 2015; 62(2): 325-31. Impact Factor 12.4 8. Balasubramaniyan V, Dhar DK, Warner AE, Vivien Li WY, Amiri AF, Bright B, Mookerjee RP, Davies NA, Becker DL and Jalan R. Importance of Connexin-43 based gap junction in cirrhosis and acute on chronic liver failure (2013) J Hepatol 58 1194-1200. Impact Factor 12.4 9. Balasubramaniyan V, Wright G, Sharma V, Davies NA, Sharifi Y, Habtesion A, Mookerjee RP, Jalan R. Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats (2012) Am J Physiol Gastrointest Liver Physiol 302(1) G145-52. Impact Factor 3.8 10. Balasubramaniyan V, Wright G, Stadlbauer V, Mookerjee RP, Davies NA, Jalan R. Reduction in hyperammonaemia by ornithine phenylacetate prevents lipopolysaccharide-induced brain edema and coma in cirrhotic rats (2012) Liver Int 32(3) 410-9 Impact Factor 4.5 11. Mookerjee RP, Balasubramaniyan V, Jalan R. The puzzle of endothelial nitric oxide synthase dysfunction in portal hypertension: The missing piece? (2007) Hepatology 46(3) 943-6 Impact Factor 14.0 Fellowships 1. Ramalingaswami Re-entry Fellowship, Department of Biotechnology, Government of India (2013- 2018). 2. George Best Postdoctoral Fellowship, Institute of Hepatology, UCL since January (2007-2013). 3. Senior Research Fellowship - Indian Council for Medical Research, New Delhi, India (2004-2006). 4. Junior Research Fellowship - UGC Major Research Project, Govt. of India (2003-2004). 5. Rameshwardasji Birla Smarak Kosh Fellowship, Medical Research Centre, Mumbai (2003).

Presentations: 

Funding: DBT, DST, ICMR and intramural research projects

Research Papers, Invited Lecture Presented at International conferences - over 50 posters and oral presentations in Asian, Australian, European, South and North America Learned Societies (liver diseases).

Staff type: 
Non-Clinical
Special Clinics: 

Membership of Professional Bodies 1. Editorial Board Member, World Journal of Hepatology 2. Member, European Association for the Study of the Liver 3. Life Member, National Teacher Training Centre for Health Professionals 4. Member, Indian Society for Heart Research 5. Member, International Society for Hepatic Sinusoidal Research 6. Life Member, Indian Society for Atherosclerosis Research Area and Interests Liver cirrhosis, Hepatic encephalopathy and Portal hypertension Inflammation and immune regulatory mechanism in liver diseases Liver cancer and cell signaling ALD&NAFLD Peer-Review DST – India Hepatology (IF-14) World Journal of Gastroenterology World Journal of Hepatology Molecular Biology and Reports European Medical Journal –Hepatology European Medical Journal -Gastroenterology Digestive liver disease

Country: 
India