Research

The Department of Pharmacology

Research in Progress:

  1. Pattern of adherence to MDI and the effect of intervention on the adherence in patients with respiratory diseases.
  2. In vitro cytotoxic effects of cleistanthins B and diphyllin on colorectal cancer.
  3. Pharmacogenetics of intravenous fentanyl for postoperative analgesia in South Indian population
  4. Study on availability, storage, dispensing practices and usage of medicine in selected public health facilities of Pondicherry.
  5. Epigenetic variations in breast cancer and response to neoadjuvant chemotherapy in a South Indian population.
  6. Evaluation of clinical significance and prognostic value of circulating tumour cells and comparison of patient derived xenograft animal models in gastric cancer patients.
  7. Effect of cleistanthins A & B on benign prostatic hyperplasia and prostate cancer: Insights into molecular mechanisms.
  8. Metformin and valproic acid combination in potentiating the anticancer activity of cisplatin non-small cell lung cancer cell lines
  9. Influence of smartphone application-based intervention on medication adherence in patients with chronic diseases- A randomized controlled trial.
  10. Association of calcium channel modulator protein1 (ORAI1) 546C>T and histamine H1 receptor (HRH1) – 17 C>T genetic polymorphisms with the efficacy and safety of non-sedating H1 antihistamines in chronic spontaneous urticaria patients of South Indian origin
  11. Effectiveness of drug information pamphlets in improving patient medication adherence and usage of commonly prescribed medications and antibiotics among patients in a tertiary care hospital.
  12. 5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study.
  13. Hepatoprotective effect of 7 – methoxy coumarin in paracetamol and ethanol toxicity induced cell lines.
  14. Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study.
  15. Antidiabetic and pleiotropic effects of Psidium guajava Linn leaf extract. as an add on treatment in patients with type 2 diabetes mellitus – A randomized double-blind placebo controlled trial
  16. Characterization of pncA mutation and treatment outcome among tuberculosis patients
  17. Characterization of cyclosporine trough (C0) and two-hour post dose concentration (C2) monitoring in children with idiopathic nephrotic syndrome
  18. Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR
  19. Clinical characteristics and treatment outcome of Isoniazid mono-resistance tuberculosis patients: A mixed-method study
  20. ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project
  21. The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin.
  22. Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study.
  23. Pharmacogenetics of sodium valproate – induced weight gain in South Indian patients
  24. Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients
  25. Are the users of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) at a higher risk of severe COVID-19? – A Case Control study
  26. Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients.
  27. Effect of VDR (Vitamin D Receptor) gene polymorphisms on efficacy of zoledronic acid in south Indian women with postmenopausal osteoporosis; A cross sectional study
  28. Cytogenetic and molecular characterization of teenage and young adult acute lymphoblastic leukaemia with special emphasis on identification of “Philadelphia like” profile
  29. Influence of EPHX1 c.337T>C and UGT2B7*2 genetic polymorphism on carbamazepine maintenance dose requirement in person with epilepsy from South India
  30. Estimating Incremental Cost of treating Antimicrobial Resistant infections in India
  31. Evaluation of Glycemic Index and Insulin Index of a marketed sugar product

Grants obtained (Intramural and extramural)

Extramural

S No Name of PI Amount Period of grant Agency
1 Dr M. Jayanthi Estimating Incremental Cost of treating Antimicrobial Resistant infections in India Rs. 7,33,450 2019-2021 ICMR Multicentric
2 Dr M. Jayanthi Evaluation of Glycemic Index and Insulin Index of a marketed sugar product Rs.2,70,000 2020-21 E.I.D. Parry, Chennai
3 Dr. R. Raveendran JIPMER - ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project  Rs.15,00,000 2019-20 ICMR
4 Dr. Girish. C The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin. Rs.24,62,475 2020-23 ICMR Adhoc
5 Dr Girish. C(Co-PI) Drug delivery targeting Lymphatic system: a novel nanomedicine-based approach to fight lymphatic filariasis. Rs.7,50,000 2019-22 ICMR Adhoc
6 Dr Girish. C(Co-Investigator) Isolation and characterization of Extracellular vesicles (exosomes) from human Umbilical Cord- derived Mesenchymal stem cells and determination of their Rs.60,18,600 2020-23 DST
7 Dr Mirunalini R  Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR Rs 30,000 2019-20 Tuberculosis Association of India
8 Dr Mirunalini R   Clinical outcome and microbiological profile of septic neonates receiving AWaRe group of antibiotics – Descriptive study in a neonatal ICU in South India Rs 20,000 2020 ICMR STS

  Intramural

S No Name of PI Amount Period of grant Agency
1 Dr M. Jayanthi (PhD thesis) Formulation and evaluation of topical preparation of Lawsonia inermis L. (Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients Rs. 7,50,000 2020-23 JIPMER
2 Dr M. Jayanthi (MD dissertation) 5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study. Rs. 1,99,450 2021-23 JIPMER
3 Dr.Kesavan.R (PhD thesis) Pharmacogenetics of intravenous fentanyl for postoperative analgesia in South Indian population Rs 2,25,000 2019-22 JIPMER
4 Dr.Kesavan.R (PhD thesis) Pharmacogenetics of sodium valproate-induced weight gain in South Indian patients Rs 4,00,000 2019-21 JIPMER
5 Dr.Girish.C The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin. Rs.1,75,000 2020 JIPMER
6 Dr Girish C Hepatoprotective effect of 7-methoxycoumarin in paracetamol and ethanol induced liver toxicity models in vitro.  Rs.2,00,000 2021 JIPMER
7 Dr. Harivenkatesh N (MD dissertation) Influence of smart phone application based intervention on medication adherence in patients with chronic diseases - A Randomized controlled trial Rs.2,00,000 2020 JIPMER
8 Dr.Harivenkatesh N (MD dissertation) Pharmacokinetics of colistin in patients with multidrug resistant Gram negative bacterial infections Rs.2,00,000 2020 JIPMER
9 Dr.Harivenkatesh N (MD dissertation) Pharmacokinetics of Vancomycin in patients with Methicillin Resistant Staphylococcus Aureus Infections   Rs.1,50,000 2020 JIPMER
10 Dr R.Priyadharsini(MD dissertation) Association of polymorphisms of Calcium modulator protein1 (ORAI1546C>T and Histamine H1 receptor (HRH1-17C→T genes with the efficacy and safety of non sedating H1antihistamines in chronic spontaneous urticaria patients South Indian origin Rs.1,91,000 2019-20 JIPMER
11 Dr R.Priyadharsini  (MD dissertation) Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients. Rs 1,50,000 2019-20 JIPMER
12 Dr Mirunalini R (MD dissertation) Clinical characteristics and treatment outcome of Isoniazid mono- resistance tuberculosis patients A mixed-method study Rs 50,000 2020-22 JIPMER  
13 Dr Suganthi S. (MD dissertation) Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study. Rs. 35,000 2021-21 JIPMER
14 Dr. Anusha. N (Faculty Project) Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study. Rs. 1,20,000 2021-2022 JIPMER
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Last Updated: 08 Feb 2022