Research

The Department of Pharmacology

Ongoing Research Projects:

  1. Pattern of adherence to MDI and the effect of intervention on the adherence in patients with respiratory diseases.
  2. Protective effect of gallic acid and quercetin on antitubercular drug induced liver injury and its possible mechanism in in vitro and in vivo models
  3. In vitro cytotoxic effects of cleistanthins B and diphyllin on colorectal cancer.
  4. Pharmacogenomics of Capecitabine and Oxaliplatin (CAPOX) Treatment in Colorectal Cancer
  5. Pharmacogenetics of intravenous fentanyl for postoperative analgesia in South Indian population
  6. Study on availability, storage, dispensing practices and usage of medicine in selected public health facilities of Pondicherry.
  7. Epigenetic variations in breast cancer and response to neoadjuvant chemotherapy in a South Indian population.
  8. Evaluation of clinical significance and prognostic value of circulating tumor cells and comparison of patient derived xenograft animal models in gastric cancer patients.
  9. Effect of cleistanthins A & B on benign prostatic hyperplasia and prostate cancer: Insights into molecular mechanisms.
  10. Metformin and valproic acid combination in potentiating the anticancer activity of cisplatin non small cell lung cancer cell lines
  11. Influence of smartphone application based intervention on medication adherence in patients with chronic diseases- RCT
  12. Association of calcium channel modulator protein1 (ORAI1) 546C>T and histamine H1 receptor (HRH1) – 17 C>T genetic polymorphisms with the efficacy and safety of non sedating H1 antihistamines in chronic spontaneous urticaria patients of South Indian origin
  13. Effectiveness of drug information pamphlets in improving patient medication adherence and usage of commonly prescribed medications and antibiotics among patients in a tertiary care hospital.
  14. 5- Fluorouracil Degradation Rate (5-FUDR) as a predictive biomarker for adverse effects with 5- Fluorouracil / Capecitabine therapy in South Indian cancer patients – a prospective phenotype genotype association study.
  15. Hepatoprotective effect of 7 – methoxycoumarin in paracetamol and ethanol toxicity induced cell lines.
  16. Pattern of adverse drug reaction and medication use in neonatal care units in a tertiary care hospital: a longitudinal observational study.
  17. Antidiabetic and pleiotropic effects of Psidium guajava Linn leaf extract as an add on treatment in patients with type 2 diabetes mellitus – A randomized double blind placebo controlled trial
  18. Characterization of pnc A mutation and treatment outcome among tuberculosis patients
  19. Characterization of cyclosporine trough (C0) and two hour post dose concentration (C2) monitoring in children with idiopathic nephrotic syndrome
  20. Clinical characteristics and early outcome of bedaquiline containing regimens for the treatment of MDR
  21. Clinical characteristics and treatment outcome of Isoniazid mono- resistance tuberculosis patients: A mixed-method study
  22. ICMR Rational use of medicines “Evaluation of the prescription pattern of drugs in different OPDs of a tertiary care hospital” task force project
  23. The cytokine levels and miRNA expression in patients with major depressive disorder and its modulation by silymarin.
  24. Subclinical hypothyroidism and plasma levels of commonly prescribed antiepileptic drugs – a cross sectional study.
  25. Study on availability, storage, dispensing practices and use of medicines in selected public health facilities in Puducherry.
  26. Evaluation of clinical significance and prognostic value of circulating tumour cells and comparison of patient derived xenograft models of gastric cancer patients
  27. Pharmacogenetics of sodium valproate – induced weight gain in South Indian patients
  28. Formulation and evaluation of topical preparation of Lawsonia inermis ( Lythraceae) for the evaluation of Capecitabine induced hand – foot syndrome in cancer patients
  29. Are the users of angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) at a higher risk of severe COVID-19? – A Case Control study
  30. Association of Nucleoside Diphosphate linked moiety X Type motif 15 (NUDT15) C415T and Inosine Triphosphate Pyrophosphatase (ITPA) C94A genetic polymorphisms with azathioprine induced adverse effects in south Indian patients.
  31. Cytogenetic and molecular characterization of Teenage and young adult acute lymphoblastic leukemia with special emphasis on identification of “ Philadelphia like” profile
  32. Influence of EPHX1 c.337T>C and UGT2B7*2 genetic polymorphism on carbamazepine maintenance dose requirement in person with epilepsy from South India
  33. Effect of VDR (Vitamin D Receptor) gene polymorphisms on efficacy of zoledronic acid in south Indian women with postmenopausal osteoporosis; A cross sectional study