Research

The Department of Pathology


Publications (Last three years) 236

 

Research Projects Last three years
Completed 34
Ongoing 29

Research Projects(completed during last 3 years between 2018-19& 2020-21)

  1. Clinicopathological Profile of parathyroid lesions with special reference to Ki-67 labelling index.
  2. Morphological and immunohistochemical profile of carcinoma of ampulla of Vater with special reference to expression of E-Cadherin.
  3. Prospective comparison of cytological specimen adequacy assessment by different rapid staining techniques for rapid on-site evaluation (ROSE) in Fine Needle Aspiration Cytology (FNAC) and their cost effectiveness.
  4. A prospective evaluation of the role of quantitative urine microscopy scoring system and urinary kidney injury molecule (KIM)-1 level in urinary tract infection (UTI) patients with acute kidney injury (AKI).
  5. Megakaryocticmorphology, morphometry, and Calreticulin immunohistochemistry in Myeloprolifearive neoplasms.
  6. Utility of cell population data and scatterplot patterns of automated hematology analyzers in white blood cell disorders – A comparative study with peripheral blood smears.
  7. A study of storage related changes and effect of refrigeration on hematological parameters and blood cell morphology in EDTA anticoagulated blood.
  8. Performance of H-Score in reactive lymphohemophagocytichistiocytosis (HLH).
  9. Seroprevalence of transfusion transmitted infections with special reference to Cytomegalovirus among blood donors in a tertiary care hospital.
  10. Effect of iron supplementation on hematological profile and iron indices in anemic patients with chronic kidney disease on hemodialysis.
  11. Comparison of the quality of Rapid cell block technique with conventional method in processing body fluid samples.
  12. Diagnostic utility of cytological examination in neoplastic lesions of pancreas and biliary tract.
  13. Inhibitor screening and quantification of inhibitor titres by Bethesda inhibitor assay in patients with coagulation disorders.
  14. Morphological and immunohistochemical profile of meningiomas with special emphasis on Leptin expression.
  15. Clinicopathological Profile of paraprotein associated kidney disease in monoclonal gammopathies: An Analytical Observational Study.
  16. Utility of Jones silver and Masson Trichrome stains in diagnosis of Immune complex deposits in known cases of Lupus Nephritis.
  17. Utility of tumor associated macrophages and PDL1 expression on tumor cells in prognostication of classical Hodgkin lymphoma.
  18. Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma.
  19. Diagnostic utility of fine needle aspiration cytology (FNAC) in intraoral and maxillofacial lesions.
  20. Immunophenotyping of regulatory lymphocytes and its correlation with graft function in renal transplant recipients.
  21. The expression of cancer stem cell markers Nestin and CD133 and its association with p53 expression in diffuse gliomas.
  22. Clinicopathological profile and its association with PD-L1 (Programmed cell death ligand -1) expression in non- small cell lung cancer.
  23. Expression of programmed cell death ligand 1 and CD8+ tumor infiltrating lymphocytes in patients with invasive ductal carcinoma breast, pre and post neoadjuvant chemotherapy.
  24. Assessment of the proliferative and apoptotic markers using tissue microarray and its association with treatment outcome in patients with colonic cancer.
  25. Validation of a novel alcohol- free preservative solution in comparison with conventional pre-fixative technique on quality of cytological examination of serous body fluids.
  26. Comparison of the efficacy of 1%HCl and Dithiothreitol (DTT) with conventional cytopreparatory technique in the processing of sputum samples.
  27. Effect of internal audit guided intervention in the processing and reporting of complete hemogram.
  28. “Pattern of expression of immunohistochemical markers in erythroid lineage bone marrow trephine biopsies”
  29. “Assessment of microsatellite instability in colon cancer with the help of immunohistochemical markers in a tertiary care centre of south India”
  30. “Significance of FOXP3 positive cells, Cytotoxic T cells and Macrophages in tumor microenvironment of Nodal Diffuse Large B cell Lymphoma”
  31. Standardization of Leishman-Giemsa cocktail stain and its comparison with conventional Leishman and Giemsa stains in peripheral blood and bone marrow aspirate smears.
  32. Comparison of paraffin embedded tissue immunofluorescence with fresh frozen immunofluorescence in renal pathology laboratory.
  33. Association of serum creatinine with automated and manual urine analysis parameters in patients treated with high dose methotrexate for acute lymphoblastic study- an exploratory study.
  34. Comparison of quantitative estimation of DNA extraction from formalin fixed tissue and formalin fixed paraffin embedded tissue of colorectal carcinoma using spin column method.

Ongoing Projects

  1. Bone marrow microenvironment in disease progression and therapy resistance in chronic myeloid leukemia.
  2. Immunohistochemical profile of pediatric brain tumors reflecting molecular alterations.
  3. Algorithmic approach to the diagnosis of newer primary epithelial ovarian carcinomas using apanel of newer immunohistochemical markers.
  4. A comparison between the conventional and Milan system of reporting salivary gland cytopathology for clinicopathologic and cytohistologic correlation.
  5. Structure-function relationship of hemoglobin variants and establishment of a ‘thalassemia/haemoglobinopathy registry’ in a tertiary care hospital in South India.
  6. Polymorphisms of interleukin-1 receptor antagonist (IL1RN) and multi-drug resistance (MR-1) gene in pediatric idiopathic nephrotic syndrome in Southern India.
  7. Effect of gut microbiota on the immune modulation of mononuclear cells and their correlation with renal function and graft biopsy findings in renal transplant recipients.
  8. Identification of a biomarker for IgA Nephropathy through micro RNA profiling and metabolite pathway.
  9. Prediction of renal dysfunction by urine analysis in patients treated with high dose methotrexate for acute lymphoblastic leukaemia – an Exploratory Study.
  10. Factors associated with adequacy of stem cell harvest in patients undergoing hematopoietic stem cell transplantation – an exploratory study from JIPMER intramural fund.
  11. Evaluation of the recently proposed international Sydney system of classification and reporting of lymph node cytopathology in a tertiary care hospital.
  12. Spectrum of pathological changes involving the spleen with special emphasis on splenic lymphomas- a record based descriptive study.
  13. Assessment of microsatellite instability using immunohistochemical markers and its association with clinicopathological profile among patients with endometrial carcinoma in a tertiary carecentre in South India.
  14. Assessment of NLR and PLR and its association with overall survival in patients of different grades of glioma.
  15. Assessment of the changes in the ER, PR, Her-2 neu and its association with disease outcome among patients with invasive ductal carcinoma (IDC) breast who have undergone modified radical mastectomy or breast conserving surgery post neo-adjuvant chemotherapy.
  16. Diagnostic accuracy of fine needle aspiration cytology combined with flow-cytometry in hematolymphoid lesions.
  17. Peripheral blood flow cytometric assessment of CD26 positive leukemic stem cells at diagnosis and follow up in chronic myeloid leukemia.
  18. Assessment of NLR and PLR and their association with clinico-pathological profile and disease outcome in patients with carcinoma breast.
  19. Factors associated with adequacy of stem cell harvest in hematopoietic stem cell transplantation.
  20. Polymorphism of interleukin-1 receptor antagonist (IL-1RN) gene and multi-drug resistance (MDR-1) gene in steroid-sensitive and steroid-resistant pediatric idiopathic nephrotic syndrome- a case control study in South Indian population.
  21. Immunophenotypic profile of pediatric brain tumors reflecting molecular alterations.
  22. Clinical utility of mutation specific IHC markers to predict remission status in AML patients.
  23. Clinical utility of indirect immunofluorescence and ELISA with emphasis on phospholipase A2 receptor for differentiating primary and secondary membranous glomerulonephritis.
  24. Utility of red blood cell parameters and indices of iron hemostasis in evaluation of microcytosis without anemia or with mild anemia.
  25. Comparative study on special histochemical stains by conventional and domestic microwave method.
  26. Comparison of quality of CK-7 and TTF1 immunostaining on unstained air-dried versus alcohol-fixed Papanicolaou’s (PAP) stained smears in lung adenocarcinoma.
  27. Comparative study of microwave tissue processing versus conventional tissue processing on excision specimens.
  28. Titration of monoclonal antibodies and stability of tandem dyes in cocktail preparation of flow cytometry processing.
  29. Standardization of anti Xa assay and its comparison with aPTT test for heparin monitoring.