Research
The Department of Microbiology
Research in Progress
UG projects
- Study on Escalation and De-escalation of empirical antimicrobial therapy for culture proven Blood Stream Infections
- Patterns of hospital acquired infections and their antimicrobial resistance among various intensive care units of a tertiary care hospital in South India
- Educational intervention to increase hepatitis B vaccination among SMC workers of JIPMER.
- Needle stick injuries among health care workers in a tertiary care hospital of India
- Clinico-microbial profile of fungal keratitis and detection of Pythium insidiosum- a pilot study
- Prevalence of intestinal parasitic infections in selected areas of Puducherry.
PG projects
- Speciation of the coagulase negative staphylococci isolated from blood and other sterile body fluids and their antimicrobial resistance pattern
- Clinical and microbial profile of necrotising fascitis with focus on detection of virulence genes of beta hemolytic streptococci and Staphylococcus aureus
- Role of Immunocytochemistry in detection of Mycobacterium tuberculosis antigen by fine needle aspiration cytology
- Eicosanoids, CNS inflammation, and clinical outcome in tubercular meningitis
- Diagnostic accuracy of XPERT MTB/RIF for tuberculous lymphadenitis.
- Astroglial injury and impairment of consciousness in tubercular meningitis.
- Profile of extra-pulmonary tuberculosis cases and its notification under national program in a tertiary care center, Puducherry: An operational research.
- Knowledge on Practices of Health-care-associated Infection Control among the Health Care personnel in Intensive Care Units in Tertiary Hospital , Puducherry
- Effect of hand hygiene training on Hand hygiene complete adherence rate (HHCAR) among intensive care unit staffs in a tertiary health care centre in South India
- Project on Assessment of knowledge and practice of hand hygiene practices among mothers of 0-2 years age child in an urban area of Puducherry
- Enterovirus Genotypes in Patients with Hand, Foot and Mouth Disease attending JIPMER hospital.
- The association of human papillomavirus in oral cavity and oropharyngeal squamous cell carcinoma in a tertiary hospital in south India.
- Comparison of Seroconversion Response to Hepatitis B Vaccination in Acute Lymphoblastic Leukemia during Induction and Maintenance Phase of Chemotherapy.
- Comparison of L1 based and E6/ E7 primers in detection of HPV for malignancies of Head and Neck region.
- Evaluation of HBc Ag for Occult Hepatitis B Infection with Total Anti Hepatitis B Core Antigen and Pooled Hepatitis B Virus De-oxy Ribonucleic acid (DNA) Polymerase Chain Reaction (PCR) in blood donors.
- Evaluation of Hepatitis B seroprotection status in pediatric nephrotic syndrome: A cross sectional study.
- Multiplex polymerase chain reaction for identification of Candida species from blood stream infection
- Prevalence and risk factors of Clostridium difficile infection in hospitalized patients with diarrhea, a cross sectional analytical study.
- Characterization of mutations associated with virulence and antiviral resistance in Influenza A pdm06 isolated during 2016-17 epidemic.
- Evaluation of real time polymerase chain reaction targeting mpb64 gene for diagnosis of extrapulmonary tuberculosis.
- The impact of auditing of antimicrobial stewardship programme on regulating the policy adherence and antimicrobial usage in selected intensive care units.
- Proportion of herpes simplex virus, Treponema pallidum and Hemophilusducreyi infection in patients with genital ulcer disease using conventional PCR.
- Intestinal parasitic infestation in cancer patients on treatment with special reference to Strongyloides
- Speciation and antifungal susceptibility pattern of Candida parapsilosis complex by polymerase chain reaction.
- Effect of extract of Centellaasiatica on Vibrio cholerae toxin production, gene expression and its vibriocidal effect.
- Role of antigen –antibody combination ELISA in diagnosis of Hepatitis C virus disease.
- Diagnostic accuracy of loop mediated isothermal amplification polymerase chain reaction for detection of ipah gene of Shigella from stool samples in children.
- An in vitro study of the effect of fosfomycin in combination withamikacin, ciprofloxacin and imipenem on the biofilm formed by multidrug resistant urinary isolates of Escherichia coli.
- Detection of additional reactive cases of HIV by MINI VIDAS using HIV DUO kit among serodiscordant couples.
- Speciation and detection of virulence factors among candidemia isolates by phenotypic methods.
- Determination of metronidazole susceptibility pattern of Bacteroidesfragilis group isolates obtained from anaerobic infections in a tertiary care centre, south India.
- Genotype distribution of Hepatitis B virus in a tertiary health care hospital in south India.
- Comparison of caudal administration of levobupivacaine 0.25% and 0.125% with 1 μg/kg dexmedetomidine in children for postoperative pain relief.
- Comparison of ultrasound-guided interscalene, infraclavicular and supraclavicular brachial plexus blocks: a randomized, controlled, observer-blinded study.
- Bacteremia due to obligate anaerobes following Large Bowel Surgery- A descriptive study.
- Prevalence and molecular identification of non-tuberculous mycobacteria in patients with pulmonary and extrapulmonary infections
- Clinical and microbiological characteristics and outcome of peritoneal dialysis related peritonitis.
- A study of practice pattern and complications associated with use of temporary hemodialysis catheter
- Post-operative cranial infection profile and its associated factors in elected cranial surgeries- a prospective observational study in a tertiary care center.
- Antimicrobial usage in medical wards at a tertiary care center-a prospective audit
- The Effect of Probiotics on Ventilator Associated Pneumonia – A Randomized Controlled Trial
- Knowledge on Practices of Health-care-associated Infection Control among the Health Care personnel in Intensive Care Units in Tertiary Hospital , Puducherry
- Project on Assessment of knowledge and practice of hand hygiene practices among mothers of 0-2 years age child in an urban area of Puducherry.
- Comparison of the use of three different stool preservatives on the morphology of intestinal parasites.
- A study of ventilator associated pneumonia in medical intensive care unit with special reference to non-fermentative Gram negative bacilli.
PhD projects
- Reduced susceptibility or resistance to vancomycin in Gram positive cocci: mechanisms and risk factors
- Genetic diversity and pathogenicity of
- Prevalence, genetic diversity and pathogenesis study of Blastocystis in humans.
- Molecular epidemiology, genetic diversity and drug resistance in symptomatic and asymptomatic carriers of Giardiaspp – community based study.
- Antimicrobial resistance and molecular characterization of clinical and asymptomatic carrier isolates of group A beta hemolytic streptococci
- Development and evaluation of Loop mediated isothermal amplification (LAMP) assay for the diagnosis of meningitis and community acquired pneumonia due to Streptococcus pneumoniae
- Study of virulence pattern, antimicrobial resistance and genetic relatedness of Escherichia coli isolated from diarrhoeal stool samples
- Genetic analysis of virulence factors in Shigella
- Study of bacterial stress response (SOS) with respect to horizontal gene transfer in Vibrio cholerae
- Whole genome sequence analysis of haemolyticus with special reference to mobile genetic elements affecting virulence, antimicrobial resistance and clonality.
- Whole genome sequencing of clinical and environmental isolates of Burkholderia pseudomallei and seroprevalence of melioidosis in selected high risk population in and around Puducherry.
- Study of ventilator associated pneumonia with special reference to non fermentative Gram negative bacilli
- Detection of heteroresistant vancomycin intermediate Staphylococcus aureus (hVISA) by the population analysis profile- area under curve (PAP-AUC) analysis
- Development of loop mediated isothermal amplification assay for rapid diagnosis of meningitis and pneumonia due to Streptococcus pneumoniae
- Whole genome sequence analysis of Staphylococcus haemolyticus with special reference to mobile genetic elements affecting virulence and resistance and clonality
- Whole genome sequencing of clinical and environmental isolates of Burkholderia pseudomallei and seroprevalence of melioidosis in selected high risk population in and around Puducherry
Faculty projects
- Pyrexia of unknown origin - a prospective study in JIPMER
- Comparison of diagnostic accuracy of faecal swab, conventional dry sampling method and PCR for intestinal parasites – a pilot study (2016 – 18)
- Inflammatory biomarkers as a triage test for screening symptomatic TB (2017-18)
- A multicenter phase II/III double-blind, randomized, placebo controlled study to evaluate the efficacy and safety of VPM1002 in the prevention of tuberculosis (TB) recurrence in pulmonary TB patients after successful TB treatment in India (2017-18)
- Biomarkers for Risk of TB and for TB Treatment Failure and Relapse. It is an Indo- US Vaccine Action Program (VAP) Initiative on Tuberculosis Research: Regional Prospective Observational Research for Tuberculosis
- Predictors of Resistance Emergence Evaluation in Multidrug Resistant-Tuberculosis Patients on Treatment
- Comparison of SPAN Diagnostics and TUBERSOL purified-protein derivative (PPD) skin test (TST) antigen solutions in detecting latent tuberculosis infection in India (2016-18)
- A Multi-Centric Hospital Based Study on Epidemiology of Keratoconjunctivitis in India.
- Study of save our souls (SOS) bacterial stress response with reference to horizontal gene transfer in Vibrio cholera (2018-2021)
- Tuberculosis - Learning the impact of Nutrition (TB-LION) (2018-2022)
Grants obtained (Intramural and extramural)
- Sujatha S. received grants of
- 2.77 crores from Indian Council of Medical Research for the project ‘Nodal coordinating centre for surveillance of antimicrobial resistance in Staphylococcus and Enterococcus species’.
- Jharna Mandal received grants of
- 3 lakhs from JIPMER for the project ‘Determination of the mechanisms of quinolone resistance in Shigella species.’
- Study of save our souls or SOS bacterial stress response with reference to horizontal gene transfer in Vibrio cholerae. – CSIR, an amount of 9,25,00 INR
- Rakesh Singh received grants of
- Rs 2000/ per completed case from Fungal infection study Forum (FISF) for the project ‘Multicenter observational study on epidemiology, treatment and outcome of Mucormycosis in India’.
- Dr Rahul Dhodapkar received grants of
- 16 crores from the Department of Health Research for the project ‘Establishment ofRegional Virology Network Laboratoryfor Establishment of a network of Laboratories for managing epidemics and Natural Calamities (VRDL)
- A Multi-Centric Hospital Based Study on Epidemiology of Keratoconjunctivitis in India by DHR as Coordinating centre Amount - 1.3 cr
- Regional Influenza laboratory - 11 lakhs
- State Surveillance Hospital for Arboviral infections - Dengue & Chikungunya - 1 lakh
- Dr Noyal Mariya Joseph received grants of
- 35,72,770/- from Public Health England for the project ‘Validation of host differentially expressed biomarkers of tuberculosis for patent exemplification and PoC diagnostic test development.’
- Nonika Rajkumari received grants of
- Rs 1.63 lakhs from JIPMER, for the project ‘Comparison of diagnostic accuracy of faecal swab, conventional dry sampling method and PCR for intestinal parasites – a pilot study