Research
Department is actively involved in various research undertakings viz. investigator initiated projects, sponsored clinical trials, multicenter collaborative projects, collaborative clinical trial network in areas of clinical studies, basic biology, regulatory trials and integrative research. Department faculty have secured both extramural and intramural grants to support the research activities. List of recently completed and ongoing projects in different disease specific areas is summarized in the table below
Projects completed in last five years
- Evaluation of Vitamin D Supplementation in Affecting the Outcome of Newly Diagnosed Patients with Lymphoma
- Predictors of chemotherapy toxicity in elderly patients
- Intensive Oral Hygiene Interventions During Therapy of Acute Leukemia May Result in Detrimental Outcomes – A Randomized Clinical Trial
- Role of CYFRA 21-1 and CEA as prognostic and predictive markers in locally advanced and metastatic gastric carcinoma
- Assessment of Late Effects in Childhood Cancer Survivors
- Comparison of the efficacy of olanzapine, metoclopramide and domperidone for the symptom abolishment of chemotherapy induced breakthrough nausea and vomiting (CINV): a randomized clinical trial.
- Level of anxiety and depression and its clinical and socio-demographic determinants among the parents of children with cancer undergoing chemotherapy
- Comparison of efficacy of aspirin plus EOX vs EOX alone in patients with locally advanced and metastatic gastric cancer – a randomized clinical trial
Intramural Funded Projects (Ongoing)
- Chemotherapy induced osteoporosis and its association with genotypes among postmenopausal breast cancer patients
- Effect of neoadjuvant treatment with zoledronic acid and chemotherapy in women with locally advanced triple negative breast cancer
- Effect of sepsis bundle-based protocol on clinical outcomes of very high risk febrile neutropenia
- Study of Immune regulatory mechanisms in Acute Myeloid Leukemia (AML) with emphasis on Vitamin D mediated pathway and association with clinical outcomes
- Efficacy of olanzapine when added to nutritional advice in reducing anorexia in patients undergoing chemotherapy for gastric, hepato-pancreaticobiliary and lung cancer- A randomized double-blind placebo-controlled trial
- Efficacy of weekly paclitaxel in combination with daily oral sodium valproate in relapsed and refractory lymphoma patients- A phase II study
- Phase II Trial On GV-Dexa In Relapsed Refractory Hodgkins’ Lymphoma
- Phase III trial of early vs. delayed treatment in biochemical relapse of myeloma
- Thalidomide for the prevention of chemotherapy induced nausea and vomiting (CINV) in the second cycle among patients receiving Highly Emetogenic Chemotherapy (HEC) and having any nausea in the first cycle: A Randomized, Double blind, Placebo-controlled trial
- Tolerability adapted Induction Regimen for newly diagnosed borderline fit Acute Myeloid Leukemia: a Pilot study of safety and efficacy (TAMe AML)
- Extramural Projects (Ongoing)
| Name of the project | PI | Funding agency |
|---|---|---|
| 1. A global, multicenter, three arms, open-label randomized study to evaluate the efficacy and safety of Nanosomal Docetaxel Lipid Suspension compared to Taxotere® (Docetaxel Injection Concentrate) in triple-negative breast cancer patients with locally advanced or metastatic breast cancer after failure to prior chemotherapy | Dr. Biswajit D | INTAS pharma |
| 2. Pattern of microbial dysbiosis in gastric cancer -A multicentric study | Dr. Biswajit D | ICMR |
| 3. Autophagy as a Target for Therapy in Ovarian Cancer: A Phase II Randomized Trial with Biomarker Correlation | Dr. Prasanth Ganesan | ICMR |
| 4. Integrated analysis of epigenetic, protein expression and metabolic mechanisms of drug resistance in relation to apoptotic pathway in acute lymphoblastic leukemia | Dr. Smita Kayal | ICMR |
| 5. Network of Oncology Clinical Trials India | Dr. Prasanth Ganesan | BIRAC (National Biopharma Mission) |
| 6. National Cancer Tissue Biobanking Project | Dr. Biswajit D | Collaboration with IIT Chennai +DST, DBT |
| 7. A prospective, multicenter, randomized, double blind, Phase III study to compare the efficacy and safety of Biosimilar Bevacizumab of Enzene Biosciences Ltd. Versus Innovator Bevacizumab both in Combination with CAPEOX in patients with Metastatic Colorectal Cancer | Dr. Smita Kayal | ALKEM Pharmaceuticals |
| 8. Post-marketing Phase 4 Study to Evaluate Safety, Tolerability, and Efficacy of Kyprolis® (Carfilzomib) in Indian Patients With Relapsed or Refractory Multiple Myeloma: A Prospective, Open-label, Non-comparative, Multicenter Study | Dr. Biswajit D | |
| 9. Phase 4 study of daratumamab in relapsed myeloma | Dr. Prasanth Ganesan | Janssen Pharma |
| 10. Phase 4 Study of Ibrutinib in CLL and relapsed Mantle Cell Lymphoma | Dr. Prasanth Ganesan | Janssen Pharma |
| 11. Understanding the Immune-regulatory pathways in Acute Myeloid Leukemia with relation to Vitamin D and their association with Clinical Outcomes | Dr. Smita Kayal | DST - SERB |